AKT1 and cardiac hypertrophy: Consistent with this conclusion are the reports that ventricular myocytes obtained from endotoxemic guinea-pigs [21] and septic pigs [22] show marked reduction in L-type calcium current; whereas, Akt/PKB overexpression in transgenic mice results in cardiac hypertrophy, increased amplitude of Ca2+ transients and enhanced L-type membrane Ca2+ currents [23].