WDR13 and Hyperinsulinemia: Although our in-vitro data in MIN6 cells as well as hyperinsulinemia and better glucose clearance in Wdr13 knockout mice show functional significance of WDR13 protein in pancreatic beta cells, a tissue-specific knockout of Wdr13 gene will be necessary to confirm that the gross changes observed by us in the mutant mice are direct consequences of alterations in beta cell function in these mice.