Interestingly, another earlier study reported an induced expression of HLA class I molecules on erythrocytes in patients with HIV infection due to the effect of increased endogenous production of interferon-α [64]; thus supporting a possible interaction between the induced HLA class I molecules on infected erythrocytes and KIR on NK cells in malaria co-infection with HIV; however, this hypothesis needs to be further tested. This evidence concerns the gene KIR3DL1 and HIV infectious disease.