Collectively, the results suggest that inhibitory KIR2DL2 and KIR2DL3, which are alleles of the same locus, play a role in the inverse effects on PM and PM/HIV co-infection, and the effect of KIR gene content polymorphisms on PM in HIV-1 women is dependent on high CD4 counts. This evidence concerns the gene KIR2DL3 and coinfection.