IL37 and Autoimmunity: The traditional view of an initiating role of IFNγ, IL-12 and Th1 cells in immune-mediated human and disease models of autoimmunity has been revised both by human genetic association studies implicating the IL-23 pathway, as well as the requirement for IL-23, and not the IL-12 pathway, in mouse models of intestinal, dermatologic and central nervous system inflammation [16], [17], [18], [19].