Within IBD, a striking number of the top association signals include genes along the IL-23 signaling pathway, including STAT3, IL12B (p40, a component of the heterodimeric IL-23 cytokine; also part of IL-12), JAK2 and TYK2[6], [7], [8], although these genes are not specific to IL-23 signaling. The gene discussed is IL37; the disease is inflammatory bowel disease.