Relative to the control group, the HF group significantly decreased expression of 11 genes [adenylate cyclase activating polypeptide 1 (pituitary) receptor 1 (Adcyap1r1), adrenergic beta-1-receptor (Adrb1), agouti related protein homolog (Agrp), apolipoprotein A-IV (Apoa4), ciliary neurotrophic factor receptor (Cntfr), growth hormone receptor (Ghr), ghrelin/obestatin prepropeptide (Ghrl), insulin 1 (Ins1), leptin receptor (Lepr), nuclear receptor subfamily 3 group C member 1 (Nr3c1), and sortilin 1 (Sort1)] and increased that of interleukin 1 beta (IL-1β) (P<0.05, Figure 3B). The gene discussed is LEPR; the disease is hydrops fetalis.