A similar pattern of expression was also observed in the liver (Figure 4), although the levels of IFN target genes were strikingly higher in KO mice than WT mice for many genes, with fold changes of genes such as adenosine deaminase, CXCL10, guanylate-binding proteins (Gbp)-1 and −2, 2’5’ OAS and the Mx proteins being an order of magnitude higher in KO mice by day 2 post-infection. This evidence concerns the gene SMOC1 and infection.