IDO1 and neoplasm: Factors contributing to these partial responses include down-regulation of MHC and antigen presentation by tumor cells, their resistance to T cell delivered death signals, and tumor production of immunosuppressive factors such as vascular endothelial growth factor (VEGF), Indoleamine-pyrrole 2,3-dioxygenase (IDO), IL10 and transforming growth factor-beta (TGFβ)[4,5].