Reg IV functions as a potent activator of the EGFR/Akt/AP-1 signaling pathway in several types of cancer cells and increases the expression of Bcl-2, Bcl-xl, and surviving proteins, related to the inhibition of apoptosis, suggesting that it may act as a tissue mitogen or play a role in the cell growth [21]. This evidence concerns the gene AKT1 and cancer.