REG4 and central nervous system cancer: Firstly, Reg IV was up-regulated in human glioma tissues compared with non-neoplastic brain tissues at both mRNA and protein levels; Secondly, the increased Reg IV expression in glioma tissues was significantly correlated with advanced tumor progression and aggressive clinicopathological features; Thirdly, the results of Kaplan-Meier analyses shown that glioma tissues with high Reg IV expression tend to have poorer overall survival.