When adjusting for HCV genotype, baseline levels of HCV RNA load and ALT, baseline age, gender, infection time, fibrosis, the G allele of rs8099917 was the most significant factor for predicting NVR and REL (OR = 14.02, 95% CI = 3.35–58.65, P < 0.0001 for NVR versus SVR and OR = 2.27, 95% CI = 1.13–4.58, P = 0.022 for REL versus SVR, respectively). Here, GPT is linked to fibrosis.