Moreover, in a subsequent research by the same authors, the addition of small doses of metformin- 850mg/day to the treatment with DRP/EE30μg for 3 months failed to attenuate body adiposity of PCOS subjects and was accompanied by a further deterioration of TG and interleukin-6 (IL-6) levels from the norm [33]. The gene discussed is IL6; the disease is polycystic ovary syndrome.