Sustaining our results, it was shown that a 4–5% weight loss improved lipid, glucose, and insulin profiles in women with and without PCOS, but was not effective in lowering CRP concentrations in PCOS women [45] whereas a 15% weight loss in a 2-yr dietary and exercise intervention study was associated with hsCRP reduction [46]. This evidence concerns the gene INS and polycystic ovary syndrome.