A 68 years old woman who experienced ALT/AST elevation to 693.1/510.2 U/L after 35 days of anti-TB treatment was with no improvement after hospitalization and finally died of hepatic failure on the 45th day; another 69 years old man who experienced ALT elevation to 210 U/L with jaundice after 65 days of anti-TB treatment died after 1 week in hospital. The gene discussed is GPT; the disease is Jaundice.