However, the Mucinous-subtype retains important factors usually found in poor prognostic tumors; a) mucinous tumors have worse clinical outcome and in our study mucinous and MSI tumors clustered together; b) high levels of SPP1, FAP, GREMLIN1, CD55 or REGIV among others have been reported to be associated with cancer invasion, metastasis and poor prognostic in colon cancer [39-45]. This evidence concerns the gene REG4 and cancer.