This study aimed to investigate whether CSE1L, DIDO1 and RBM39 may drive 20q amplification.<h4>Methods</h4>Protein expression levels were examined by immunohistochemical evaluation of tissue microarrays containing a series of colorectal adenoma and carcinoma samples, which were characterized by genome-wide (microarray-based) DNA and mRNA profiling.<h4>Results</h4>CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. The gene discussed is CSE1L; the disease is colorectal adenoma.