Thus, the anti-proliferative effect of Tob1 in gastric cancer might be due to the decreased expression of cyclin D1 and CDK4, and the increased expression of p15, while the anti-migratory and anti-invasive potential of Tob1 may be mediated through the inhibition of uPAR and PPARδ in gastric cancer cells. This evidence concerns the gene PPARD and gastric cancer.