The effect of miR-497 on the expression of IGF1-R in colon cancer cells was further consolidated by examination of representative colon cancer tissues that expressed increased levels of miR-424 (>2 times) compared with normal mucosa and were sampled by relatively low (n=5) and high (n=5) levels of miR-497 (Figure 1c; Supplementary Figure 6). The gene discussed is IGF1R; the disease is colonic neoplasm.