IGF1R and tongue squamous cell carcinoma: Recent studies have pointed to a role of microRNAs (miRs) in post-transcriptional regulation of IGF1-R.13, 14, 15, 16 While a group of miRs including miR-470, miR-669b and miR-681 are involved in repression of IGF1-R in long-lived mutant mice,13 miR-375 and miR-7 target IGF1-R in oesophageal and tongue squamous cell carcinoma cells, respectively.14, 16 In addition, miR-145 targets the docking protein of IGF1-R, insulin receptor substrate-1, thus inhibiting IGF1-R signalling.17