TP53 and malignant colon neoplasm: Consistently, downregulation of miR-497 and miR-195 as a consequence of copy number reduction of chromosome 17p13.1 has been reported in peritoneal carcinoma cells.44 Of note, the tumour suppressor gene TP53 also maps to the same fragment of chromosome 17p13.1, which is frequently underexprssed in colon cancer cells.45 Together, these results suggest that deletion of the segment of chromosome 17p13.1 may have a role in colon cancer tumorigenesis, whereas miR-497 and miR-195, like p53, may have potential roles as tumour suppressors.