Members of this miR family share the same 3′UTR binding seed sequence and have been reported to cooperatively regulate a number of targets, including CDK6, CARD10 and CDC27 leading to regulation of cell proliferation in concert in colon cancer cells.30 Similarly, miR-15, -16, -195 and -497 have been shown to target Bcl-2, thus promoting induction of apoptosis, although these findings were made in different cell types.27, 31, 32, 33, 34 However, unlike miR-497, miR-15, -16, -195 and -424 did not appear to target the 3′UTR of IGF1-R in colon cells. This evidence concerns the gene CDC27 and colonic neoplasm.