POMC and adrenal gland hyperfunction: A central to peripheral plasma ACTH ratio exceeding 2 (or 3 after stimulation by CRH) is in favor of Cushing’s disease[37-40] .In case of ACTH dependent hypercortisolism, if the initial etiologic workup is not in favor of a pituitary origin, complementary morphologic investigation including tomodensitometric whole body examination should be performed.