Glomerular filtration rate <45 ml/min/1.73 m2, age ≥ 61 years, cardiovascular disease (CVD), diabetes, C-reactive protein (CRP) ≥5 mg/L, haemoglobin ≤110 g/L, p-albumin ≤ 35 g/L and overweight were associated with impaired HRQoL. The gene discussed is ALB; the disease is diabetes mellitus.