Moreover, RPL26 plays a role in enhancing p53 mRNA translation during the DNA damage response by direct interactions with both MDM2 protein and p53 mRNA [66].Hence, ribosomal proteins have more dynamic roles in regulating the p53 tumor suppressor pathway than was previously thought and this complex interaction appears to be the most significant extraribosomal function of the ribosomal proteins, through which they exert an effect on the cell cycle and apoptosis. The gene discussed is TP53; the disease is neoplasm.