Models VARI-LTM-044 colorectal cancer and VARI-LTM-034 pancreatic cancer both had a single KRAS mutation; melanoma models VARI-LTM-086 and VARI-LTM-027 had BRAF and NRAS mutations, respectively (Table 3). The gene discussed is BRAF; the disease is familial pancreatic carcinoma.