Moreover, positive TRAIL-R4 expression is correlated with tumoral grade in BC patients with invasive ductal carcinoma [61], the expression of TRAIL-R is associated with the resistance of MCF-7 cells to the action of TRAIL and the expression of TRAIL-R3/R4 could compete with TRAIL-R1 and/or -R2 to binding TRAIL blocking apoptosis signaling [62,63]. The gene discussed is TNFRSF10D; the disease is breast cancer.