Taken together, these results suggest that Kaiso and p120ctn contributes to maintaining the undifferentiated state of the CML-BP and Kaiso seems to be a central molecule involved in broad regulation of differentiation and proliferation genes in CML-BP and also probably related to imatinib resistance. This evidence concerns the gene CTNND1 and chronic myelogenous leukemia, BCR-ABL1 positive.