The impact of SULT1A1 rs9282861 genotype on the risk of breast cancer and response to TAM therapy has been reported in several studies; the variant AA genotype has been associated both with poorer overall survival (OS) [8] and with no effect on OS [9,10], whereas patients with the homozygous wild-type GG genotype have been reported to have a tendency towards improved distant recurrence-free survival (RFS) [11]. This evidence concerns the gene SULT1A1 and breast carcinoma.