For example, Figure 2 shows haematoxylin and eosin stained sections from the pancreas of Men1+/−: Trp53+/+ and littermate Men1+/−: Trp53+/− animals, including some large, highly vascular adenomas, but notably some smaller and histologically normal islets are still apparent in each of these animals. The gene discussed is MEN1; the disease is adenoma.