No postnatal tumor development was observed inchimeric mice obtained from iPSCs without introduction of c-Myc ,whereas oncological diseases developed in ~15% of the animals obtained from iPSCswith exogenous c-Myc  [90].Oct4, Sox2 , and  Klf4  can also be associatedwith the emergence of different types of tumors; therefore, researchers increasinglytry to avoid the transduction of these oncogenes [54, 56, 61, 91]. Here, MYC is linked to neoplasm.