Sustained virological suppression and CD4+ T cell count recovery is the main objective of HAART.55 In HIV-infected patients, daily co-trimoxazole should to be prescribed as prophylaxis against major opportunistic infections when CD4+ T cells are less than 200/μl;57 however several findings demonstrated that daily co-trimoxazole prescription may reduce the occurrence of parasitaemia58 and clinical malaria either in adults and in children.59,60,61. The gene discussed is CD4; the disease is Opportunistic infection.