CALCA and Sepsis: In our study, PCT was also higher in clinically proven sepsis patient compared to cases of uncertain sepsis; PCT begins to increase in 2 h of sepsis onset and precedes the increased level of IL-6 and CRP.15,30 Besides, in younger children, the diagnostic value of PCT even is higher in comparison to other infectious markers such as CRP and IL-6.28 In neonates, PCT continues to rise within first 48 hours of life15, 27, 29 and even its level is also impressed by non infectious conditions including asphyxia, hypoxemia, and intracranial hemorrhage.15