IL6 and Sepsis: Evidences confirm that IL-6 levels increase rapidly after exposure to bacterial components.8, 29, 31 A very short half life of IL-6 makes it undetectable in 24 hours after the onset of illness; so a specificity and sensitivity of 89%, 67%, 58 % passes in 0, 24, and 48 hours of neonatal sepsis, respectively.22 It seems that while there are infective particles in the blood, IL-6 could be detected in order to secure the diagnosis of sepsis.