Sever inflammatory response is what the studies point to as an important cause for increased level of IL-6, hs-CRP, PCT, and WBC.8, 13–15, 17–19, 25, 29–30 There is no doubt that inflammatory biomarkers are elevated in neonatal sepsis but there are controversies if some of these combinations could play a faster role in an earlier onset phase. Here, CALCA is linked to Neonatal sepsis.