In our study, PCT was also higher in clinically proven sepsis patient compared to cases of uncertain sepsis; PCT begins to increase in 2 h of sepsis onset and precedes the increased level of IL-6 and CRP.15,30 Besides, in younger children, the diagnostic value of PCT even is higher in comparison to other infectious markers such as CRP and IL-6.28 In neonates, PCT continues to rise within first 48 hours of life15, 27, 29 and even its level is also impressed by non infectious conditions including asphyxia, hypoxemia, and intracranial hemorrhage.15 Here, CALCA is linked to intracranial hemorrhage.