Auriti et al. have reported an increased diagnostic accuracy for PCT in neonates with birth weight lower than 1500 grams;26 while López Sastre et al. concluded from one hundred infants that PCT is not sufficiently a sole marker of nosocomial neonatal sepsis and this would be a part of full sepsis evaluation.13 Simultaneous measurement of serum markers in diagnosis of early onset neonatal infection have also been suggested by combination of IL-8 and CRP by Frnaz et al.27 This evidence concerns the gene CALCA and Sepsis.