Characterization of CKIε in breast cancer has identified several somatic mutations in the 5′-coding region of the gene, which could lead to imaginal disc overgrowth in Drosophila (Dolezal et al, 2010; Foldynova-Trantirkova et al, 2010; Fuja et al, 2004). The gene discussed is CSNK1E; the disease is breast cancer.