SUN1 and mandibuloacral dysplasia with type A lipodystrophy: First, molecules involved in MADA pathogenesis are not only those regulating chromatin organization but contingently also the integral membrane proteins SUN1 and SUN2 and likely other factors implicated in nuclear positioning and nucleo-cytoskeleton interplay, a relevant aspect in adipose tissue, skin, and bone development, which are target tissues in MADA patients.