CD4 and Hepatic fibrosis: A decrease of > 20% in CD4+ cell count between the two biopsies (OR 4.88, 95% CI 1.59-15, P = 0.007), and higher ALT values at first biopsy (OR 4.16, 95% CI 1.22-14.1, P = 0.02), were significantly associated with the progression of liver fibrosis.