This observation together with the extremely heterogeneous phenotypes of SP-C deficiency, ranging from early fatal respiratory failure to children and adults chronic respiratory disease should encourage to enlarge indications of SFTPC sequencing in children and adults with chronicle respiratory symptoms and alveolo-interstitial pattern on CT-scan [7,9-11]. This evidence concerns the gene SFTPC and hyperinsulinemic hypoglycemia, familial, 4.