As GSIXII induced the expression of proapoptotic Noxa, which inhibits the survival activity of Mcl-1, we inferred that its combination with the BH3 mimetic ABT-737, which targets Bcl-2 and Bcl-xL but not Mcl-1, might improve apoptosis induction in breast cancer cells. This evidence concerns the gene BCL2L1 and breast carcinoma.