Results suggest that ICpeptides may be used to modulate calcium release in various IP3R1-associated ataxias (ataxias in which IP3R1 is less abundant, e.g., SCA15/SCA16 as well as SCA1 and SCA3, or more sensitive than in wild type mice or unaffected individuals, e.g., SCA2 and SCA3 and likely SCA1). The gene discussed is ATXN1; the disease is Ataxia.