ITPR1 and Ataxia: The models that are presented in this work can be useful for studying these emergent properties in normal physiological Purkinje neurons, as well as in ataxia. Future studies can be developed to study spontaneous Purkinje neuron firing rate or precision of spike timing and interspike intervals in various classes of ataxias with mutations in genes that code for calcium channels [9,76-78] and potassium channels [65,79], as well as IP3R1 or related proteins (including SCA1, SCA2, SCA3, SCA15/16) [3,4,6,7,9-16].