AKT1 and neoplasm: In studies with other tumors, an elevated expression level of mir-7 was an indicator of poor disease-free survival in non-small cell lung carcinoma [41], and correlated with a larger size of tumor and poor tumor grade in breast cancer tissues [42] while some reports stated that mir-7 inhibits EGFR and the AKT pathway, and the expression level of mir-7 was down-regulated expression in gilobastoma [43,44].