Therefore, we conducted detailed genetics and epigenetics analysis of the p14ARF gene in CRC tumors for which we had complete data on MSI status and DNA mismatch repair deficiency or sufficiency, and we investigated the relationships between p14ARF alterations and MSI phenotype, between p14ARF alterations and the p53 protein expression pattern and its mutational status, as well as with MDM2 protein expression. This evidence concerns the gene TP53 and colorectal carcinoma.