CDKN2A and Lynch syndrome: Of the ninety-six patients, five (5%) patients, including two of the five patients with Lynch syndrome (hereditary non-polyposis colorectal cancer (HNPCC); OMIM #120435) were carriers of a polymorphic variant corresponding to a substitution of G→A in codon 148 in exon 2 (p.Ala148Thr) affecting only the p16/CDKN2A open-reading frame.