Genetic susceptibilities and the host environment play important roles in AD, and the pathogenesis is characterized by IgE-mediated allergy and skin barrier defects.9 However, the contribution of allergen-specific IgE to the eczematous lesion remains controversial.10 The present study used immunohistochemical and double immunofluorescence studies to demonstrate numerous IgE-bearing cells in the inflammatory infiltrate of lichenified lesions in the extrinsic (IgE-allergic) form of elderly AD (Cases 1–3). Here, IGHE is linked to Alzheimer disease.