More recently we expanded on this topic demonstrating that the prognostic value of sCD40L is evident also in over 200 chronic HD patients from the RISCAVID population at 24-month followup [43] (RISCAVID, “risk cardiovascular in dialysis” is a prospective observational study performed on a large HD population in the northwestern region of Tuscany, Italy) (Figure 1). The gene discussed is CD40LG; the disease is Huntington disease.