In general, these models are based on the misexpression of human proteins such as α-synuclein [5], Tau [6, 7], and TDP-43 [8] that are present in the neuropathological hallmark lesions of patients with Parkinson's disease (PD), Alzheimer's disease (AD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis. Here, TARDBP is linked to Alzheimer disease.