Some are based on 0N3R, 0N4R, and 2N4R wild-type hTau isoforms [6, 7, 21], whereas others express mutated forms hTau, that cause autosomal dominant Tau-positive FTD, such as hTauR406W, hTauV337M, and hTauP301L [6, 22]. Here, MAPT is linked to frontotemporal dementia.