In general, these models are based on the misexpression of human proteins such as α-synuclein [5], Tau [6, 7], and TDP-43 [8] that are present in the neuropathological hallmark lesions of patients with Parkinson's disease (PD), Alzheimer's disease (AD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.