For example, Bunton et al. have demonstrated that the fibrilin-1 gene, which is involved in Marfan syndrome, plays an important role in maintaining the integrity of elastic fibers and that mutations in FIBRILIN-1 could decrease the elastin content in the aorta, providing a new mechanism for the presence of aneurysms in patients with Marfan syndrome [15]. The gene discussed is ELN; the disease is Marfan syndrome.