A rat bladder carcinoma cell line, NBT-II, can undergo EMT following addition of several growth factors including FGF1, FGF7, and FGF10 [43] and NBT-II carcinoma cell lines that were rendered autocrine for FGF1 activation had a much higher level of tumorigenicity [44]. This evidence concerns the gene FGF10 and urinary bladder carcinoma.