To our surprise, the lung cancer cell lines (Figure 4A) and the melanoma cell lines (Figure 4B) were similar in having very few methylated CpG sites in the MIG-6 promoter regulatory region, indicating that induction of MIG-6 by 5-aza-dC in melanoma was independent of DNA methylation in its promoter. This evidence concerns the gene ERRFI1 and lung carcinoma.