Using known atomic structures of fibril-forming motifs as templates, the Eisenberg lab has recently designed and characterized an all-D-amino-acid inhibitor of the fibrillization of Tau protein [48], and has presented atomic structures of fibril-forming motifs of proteins involved in Alzheimer disease in complex with small molecule binders [49]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.