Because Arf6 has been identified to play an important role in cancer cell migration [15] and the PH domain of GEP100 links EGFR signaling to Arf6 activation, it is worthwhile to explore whether the PH domain of GEP100 is involved in EGF-induced Arf6 signaling pathway and cancer cell migration ability. The gene discussed is EGF; the disease is cancer.