Among MMPs and TIMPs, TIMP-1 is frequently overexpressed and shown to serve as a prognostic marker in several types of human cancers including breast cancer, prostate cancer, lung cancer, melanoma, multiple myeloma, and glioblastoma [13], [14], [15], [16], [17], [18], [19], [20], [21]. The gene discussed is TIMP1; the disease is cancer.