Interestingly, Rac expression has been associated with resistance to erlotinib in glioma cells [36], and the combination of EGFR inhibitors with statins, which perturb Rho GTPase membrane localization and function [37], synergize to inhibit glioma cell growth irrespective of EGFRvIII and PTEN status [38]. This evidence concerns the gene AKT1 and central nervous system cancer.