To determine whether oxidative stress mediated by jacaranone contributed to the differential susceptibility of melanoma cells to ROS generation in comparison with normal cells, the oxidation of DHE was also measured in murine melanoma cells (B16F10-Nex2), murine melanocytes (melan-A) and primary culture of bone marrow macrophages from C57BL/6 mice after treatment with 50 μM jacaranone for 3 h. The gene discussed is MLANA; the disease is melanoma.