CADM1 and lung cancer: In the lung cancer cell lines, we found colocalization of two histone variants (H3.3 and H2A.Z) and histone modifications (H3K4me3 and H3K27me3) in the same nucleosome positions in the promoter region of Cadm1. This result may be a reflection of single histone variants or modifications affecting single nucleosomes within a cell line, but combinations in the same nucleosome within a cell are not unlikely.