In a lung cancer cell line with no Cadm1 gene expression, there was colocalization of histone variants (H2A.Z, H3.3) that when present as double-variant affects nucleosome stability and positioning, as well as histone modifications in which one is an activating mark (H3K4me3) and the other is a repressive mark (H3K27me3) in the same nucleosome position. Here, CADM1 is linked to lung carcinoma.