There are various studies suggesting that mutant TRPC6 is closely correlated with the mechanism of hereditary and non-hereditary nephropathies, such as focal and segmental glomerulo sclerosis (FSGS) [16], [17], [18], minimal-change disease (MCD) and membranous glomerulonephritis (MN) [19]. This evidence concerns the gene TRPC6 and focal segmental glomerulosclerosis.