Atoh8 (atonal homolog 8), Pcsk5 (proprotein convertase subtilisin/kexin type 5), Mpzl2 (myelin protein zero-like 2), TpbpB (trophoblast specific protein beta), and Spink8 (serine peptidsase inhibitor, Kazal type 8) were responsive to diet only under conditions of maternal hyperglycemia, and responsive to diabetes only under chow feeding conditions. This evidence concerns the gene PCSK5 and diabetes mellitus.