We can further classify the response patterns of these genes, as predominantly regulated by diet (in descending order of explanatory value of the diet factor): Spi16, Kcnk2, Hpgd, Ptgs2, Mmp15, or as predominantly regulated by diabetes: Pappa2, Tgfßi, Slc6a4, Crct1, Spink8, Pcsk5, and Ptges2 (again in descending order). The gene discussed is PAPPA2; the disease is diabetes mellitus.