Elevated and reduced expression levels were found for the group of genes that respond to diet under any condition but to diabetes only with breeder diet, constituted by the Kcnk2 (potassium channel subfamily K member 2), Mmp13 (matrix metallopeptidase 13), Hpgd (hydroxyprostaglandin dehydrogenase 15), and Cyp1a1 (cytochromome P450 family 1 subfamily a polypeptide 1) genes. The gene discussed is MMP13; the disease is diabetes mellitus.