Atoh8 (atonal homolog 8), Pcsk5 (proprotein convertase subtilisin/kexin type 5), Mpzl2 (myelin protein zero-like 2), TpbpB (trophoblast specific protein beta), and Spink8 (serine peptidsase inhibitor, Kazal type 8) were responsive to diet only under conditions of maternal hyperglycemia, and responsive to diabetes only under chow feeding conditions. The gene discussed is SPINK8; the disease is Hyperglycemia.