Finally, genes for which only one factor is explanatory are either responsive to diabetes only: Pla2g5, Lpl, Mmp1a, and Atoh8 fall into this group, or responsive to diet only: this subset is constituted by Ermp1, Tm9sf1, Frem1, Usp24, Adamts6, and Thbs2. Neither an interaction nor any of the single factors had significant explanatory value for expression levels of Csf2rb. Here, FREM1 is linked to diabetes mellitus.