The extent of variation in placental gene expression explained by the interaction of both factors, metabolic status x diet, varies, with decreasing importance for expression of Rassf4, Cyp1a1, Mpzl2, Thsd4, 9130005N14R, TpbpB, IL17b, Ankrd2, Pfpl, Prl5a1, and Mmp13. Of these, Cyp1a1, TpbpB, IL17b, Ankrd2, Pfpl, and Prl5a1 are more responsive to diabetes (with increasing importance of the diabetes factor), and Mmp13 is more responsive to diet. This evidence concerns the gene THSD4 and diabetes mellitus.