Of note, additional studies have indicated that not only NLRP3, but also NLRP1 [58], NLRC4 [NLR (Nod-like receptor) family CARD-containing 4] [59] and AIM2 (absent in melanoma 2) [60], [61] form the inflammasomes that drive inflammation in response to a wide variety of molecular patterns. The gene discussed is NLRP3; the disease is melanoma.