Based on our search strategy, the primary screening produced 40 potentially relevant articles, of which 12 met the inclusion criteria in an attempt to evaluate the association of CHRNA3 gene rs1051730 and/or AGPHD1 gene rs8034191 polymorphisms with lung cancer risk [5], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26]. The gene discussed is CHRNA3; the disease is lung carcinoma.