HYKK and lung carcinoma: Among these variables, the association of CHRNA3 gene rs1051730 (correlation coefficient: 0.48, P = 0.069) and AGPHD1 gene rs8034191 (correlation coefficient: 0.57, P = 0.043) polymorphisms with lung cancer risk was observed in cases with a high smoking rate under the allelic model (Figure 3).