Likewise for AGPHD1 gene rs8034191-T/C polymorphism, as compared with T allele, the C allele conferred a significant 23% increased risk for lung cancer (95% CI: 1.08–1.4; P = 0.002) with heterogeneity (I2 = 87.2%; P<0.0005). The gene discussed is HYKK; the disease is lung cancer.